It's 1820. A German doctor sets out for Venezuela to join Simon Bolivar's fight against Spain. It's not long before he's Surgeon General, manning a military hospital and overseeing the casualties, not just of war, but of tropical diseases. Chills, sea sickness. Ravaging disorders. And it's not much longer before he conjures a cure: Angostura bitters.

In the end, Dr. Siegert's secret blend of local herbs didn't really cure any fevers, but the bitters were passed down to his sons, who saw them become a crucial ingredient in classic cocktails from The Manhattan to the Old-Fashioned. They remain famous still today, but make no mistake -- they're not the only bitters on the block.